104 research outputs found
Synthesis of Highly Functionalized Allylic Alcohols from Vinyl Oxiranes and NâTosylhydrazones via a TsujiâTrost-Like âPalladiumâIodideâ Catalyzed Coupling
An unprecedented
efficient palladium(0)-catalyzed reaction of vinyl
oxiranes with N-tosylhydrazones, affording âskippedâ
allylic alcohols in total regioselectivity and stereoselectivity,
with excellent functional-group compatibility, is reported. In this
TsujiâTrost-like allylation, we propose the use of N-tosylhydrazones as a synthetic equivalent of α-styryl
anions. More than 20 new products are described, including naturally
occurring derivatives. A catalytic system involving an iodide (Iâ) source is necessary to sustain the catalytic cycle
Recent Progresses in the Preparation of Chlorinated Molecules: Electrocatalysis and Photoredox Catalysis in the Spotlight
Among halogenated molecules, those containing chlorine atoms are fundamental in many areas such as pharmaceuticals, polymers, agrochemicals and natural metabolites. Despite the fact that many reactions have been developed to install chlorine on organic molecules, most of them rely on toxic and hazardous chlorinating reagents as well as harsh conditions. In an attempt to move towards more sustainable approaches, photoredox catalysis and electrocatalysis have emerged as powerful alternatives to traditional methods. In this review, we collect the most recent and significant examples of visible-light- or current-mediated chlorination published in the last five years
- âŠ